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Arianna Giacomini Selected Research

Fibroblast Growth Factors (Fibroblast Growth Factor)

1/2021The FGF/FGFR system in the physiopathology of the prostate gland.
1/2021Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88.
12/2020Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress.
1/2020FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress.
9/2019The Autocrine FGF/FGFR System in both Skin and Uveal Melanoma: FGF Trapping as a Possible Therapeutic Approach.
1/2018Long Pentraxin 3-Mediated Fibroblast Growth Factor Trapping Impairs Fibrosarcoma Growth.
1/2018Future applications of FGF/FGFR inhibitors in cancer.
11/2017Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach.
1/2016Blocking the FGF/FGFR system as a "two-compartment" antiangiogenic/antitumor approach in cancer therapy.
1/2016Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors.
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Arianna Giacomini Research Topics

Disease

33Neoplasms (Cancer)
01/2022 - 09/2009
5Prostatic Neoplasms (Prostate Cancer)
01/2022 - 06/2013
5Multiple Myeloma
05/2021 - 11/2018
3Globoid Cell Leukodystrophy (Krabbe Disease)
12/2019 - 09/2013
3Lymphoma (Lymphomas)
07/2013 - 01/2013
2Melanoma (Melanoma, Malignant)
11/2020 - 12/2013
2Fibrosarcoma
09/2019 - 01/2018
2Breast Neoplasms (Breast Cancer)
07/2017 - 11/2012
2Necrosis
07/2013 - 11/2012
1Urinary Bladder Neoplasms (Bladder Cancer)
12/2021
1Wounds and Injuries (Trauma)
01/2021
1Hematologic Neoplasms (Hematological Malignancy)
01/2021
1Waldenstrom Macroglobulinemia (Macroglobulinemia)
01/2021
1Lung Neoplasms (Lung Cancer)
12/2020
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2020
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2020
1Skin Neoplasms (Skin Cancer)
11/2020
1Nevus (Nevi)
11/2020
1Hypoxia (Hypoxemia)
01/2020
1Sphingolipidoses (Sphingolipidosis)
12/2019
1Inflammation (Inflammations)
09/2019
1Uveal melanoma
09/2019
1Monosomy
09/2019
1Hepatocellular Carcinoma (Hepatoma)
09/2019
1Sarcoma (Soft Tissue Sarcoma)
01/2018
1Carcinoma (Carcinomatosis)
05/2015
1Nervous System Diseases (Neurological Disorders)
09/2013
1Neoplasm Metastasis (Metastasis)
11/2012
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
11/2011
1Non-Hodgkin Lymphoma (Lymphosarcoma)
11/2011

Drug/Important Bio-Agent (IBA)

13Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
01/2021 - 06/2013
8Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
01/2021 - 12/2013
8LigandsIBA
12/2020 - 03/2010
6Biological ProductsIBA
12/2021 - 01/2015
6PTX3 proteinIBA
05/2021 - 06/2013
6Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
09/2019 - 06/2013
4GalactosylceramidaseIBA
11/2020 - 09/2013
3Tyrosine Kinase InhibitorsIBA
12/2020 - 01/2015
3EnzymesIBA
11/2020 - 09/2013
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2013 - 03/2010
2enzalutamideIBA
01/2022 - 01/2020
2AndrogensIBA
01/2022 - 05/2015
2Protein Isoforms (Isoforms)IBA
12/2021 - 11/2021
2Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2020
2CytokinesIBA
01/2020 - 01/2020
2Pharmaceutical PreparationsIBA
07/2019 - 09/2009
2Biotin (Vitamin H)FDA Link
11/2018 - 03/2010
2Pattern Recognition ReceptorsIBA
01/2018 - 05/2015
2Psychosine (Galactosylsphingosine)IBA
10/2015 - 09/2013
2Sorafenib (BAY 43-9006)FDA Link
01/2013 - 09/2009
2hexanoic acid (hexanoate)IBA
03/2010 - 09/2009
1pemigatinibIBA
01/2022
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
12/2021
1Carbonic Anhydrase IXIBA
12/2021
1MonosaccharidesIBA
12/2021
1Biomarkers (Surrogate Marker)IBA
12/2021
1Antisense OligonucleotidesIBA
11/2021
1erdafitinibIBA
12/2020
1SphingolipidsIBA
11/2020
1Monophenol Monooxygenase (Tyrosinase)IBA
11/2020
1CeramidesIBA
11/2020
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
11/2020
1Microphthalmia-Associated Transcription FactorIBA
11/2020
1Phosphates (Orthophosphate)IBA
08/2020
1fosbretabulin (combretastatin A4)IBA
08/2020
1Androgen Receptor AntagonistsIBA
01/2020
1macitentanIBA
01/2020
1Bortezomib (Velcade)FDA Link
01/2020
1AntioxidantsIBA
01/2020
1CatalaseIBA
01/2020
1Vitamin EFDA LinkGeneric
01/2020
1Endothelin-1 (Endothelin 1)IBA
01/2020
1HydrolasesIBA
12/2019
1Complement C3 (C3 Complement)IBA
09/2019
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
09/2019
1IronIBA
09/2019
13,4-dihydroxybenzohydroxamic acidIBA
09/2019
1Chelating AgentsIBA
09/2019
1triphosphoric acid (triphosphate)IBA
09/2019
1CarcinogensIBA
08/2019
1MicroRNAs (MicroRNA)IBA
05/2019
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2015
1Hormones (Hormone)IBA
05/2015
1SteroidsIBA
05/2015
1AntibodiesIBA
01/2015
1Mevalonic Acid (Mevalonate)IBA
03/2014
1perifosineIBA
07/2013
1TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
07/2013
1Dihydrotestosterone (Androstanolone)IBA
06/2013
1Cytostatic AgentsIBA
01/2013
1Estrogen ReceptorsIBA
11/2012
1Yttrium-90IBA
11/2011
1ibritumomab tiuxetan (Zevalin)FDA Link
11/2011

Therapy/Procedure

14Therapeutics
01/2022 - 09/2009
2Castration
01/2022 - 01/2020
1Quantum Dots (Quantum Dot)
12/2021
1Drug Therapy (Chemotherapy)
01/2020
1Heterologous Transplantation (Xenotransplantation)
07/2013